Marfan syndrome and other connective tissue disorders

Marfan syndrome is a condition that affects the body’s connective tissue. It is an inherited condition which has an incidence of about one in 5,000 people. In about 25% of cases the condition occurs spontaneously and there is no family history.

Because there is connective tissue throughout the body, Marfan syndrome can affect many of the body’s systems, including:

the skeleton
the eyes
the skin and lungs.

It can also affect the heart and blood vessels. It can therefore have life-threatening consequences, notably dilation of the aorta and mitral valve insufficiency that may lead to aortic aneurysm and dissection.

The ExoVasc® PEARS has been used to treat patients with aortic dilation caused by Marfan syndrome and other genetic conditions such as Loeys-Dietz and Ehlers-Danlos syndrome.

More about the Aortic PEARS procedure

Find out more about the procedure.

Patient stories

More than 1,100 people have had an ExoVasc® PEARS implanted. Some of them have shared their stories and experiences.

Patient benefits brochure

You may find our patient benefits brochure useful when discussing the ExoVasc® PEARS with your doctor.

Where you can get the ExoVasc® PEARS

We develop medical devices that manage aortic dilation and minimise the risk of aortic dissection.

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The staff of Exstent Limited are not medically qualified and are thus not able to provide clinical advice or answer questions of a clinical nature. We may direct your attention to publications in peer-reviewed journals that provide clinical information or provide information based upon personal experience. However, for any questions of a clinical nature patients are recommended to consult a qualified clinician.